Final Meeting 3-5 July, 2009, Florence.

This will be an open conference, mainly devoted to the presentation of the final results and to pave the way for further collaborations.

Final Meeting flyer available here.

Photographs from the final meeting available here.

Agenda of Final Meeting

3 July 2009

15.30 - 16.00 Welcome (E.Cerbai)

• Update on the scientific and administrative report

16.00 - 17.00 WP2 Normal and abnormal rhythm generation (Chairperson: D DiFrancesco)

• A. Barbuti (Milan) - The functional and molecular properties of ESC-derived pacemaker cardiomyocytes are suitable for the generation of a biological pacemaker
• M. Baruscotti (Milan) - Identification of SNPs in the human HCN4 gene
• P. Camelliti (Oxford) - Mapping tissue structure and function in different caridac research model systems

17.00 Coffee

17.30 - 19.00 WP3 Transgenic animals for HCN research (Chairperson: M. Biel)

• M. Biel (Munich) - Transgenic HCN channel mouse lines
• S. Herrmann (Munich) - HCN channels in caridac pathophysiology - insights from mouse models
• M. Baruscotti (Milan) - Electrophysiological characterisation of pacemaking activity of HCN4 knockout mice

20.30 Dinner (at Relais Certosa)

4 July 2009

9.00 - 10.00 WP4 HCN - selective bradycardic drugs (Chairperson: D DiFrancesoc)

• M.N. Romanelli, E. Cerbai (Firenze) - Synthesis of isoform-selective HCN blockers: chemical design and pharmacological characterisation
• A. Varro (Szeged) - Electrophysiological effects of different HCN blockers in ventricular preparations

10.00 Coffee

10.30 - 12.30 WP5 Pathways and Mechanism leading to electrical remodelling (Chairperson: U. Ravens)

• U. Ravens (Dresden) - Skeletal muscle-derived progenitor cells as putative model for stretch-induced differentiation? An electrophysiological characterisation
• A. Trafford, K. Dibb, D. Eisner (Manchester) - Atrial remodelling in disease: mechanisms of arrhythmogenesis
• U. Schotten (Maastricht): Ventricular rate control during AF with the adenosine-receptors agonist CVT510
• E. Wettwer (Dresden): NCX in atrial myocytes from SR and AF patients: Effects of the selective NCX-blocker SEA-0400

12.30 Lunch

14.30 - 15.30 WP6 Contractile remodelling in atrial fibrillation (Chairperson: U. Schotten)

• U. Schotten (Maastricht) - Alterations of Ca handling due to tachycardia-induced atrial remodelling in rabbits
• C. Ferrantini, C. Poggessi (Firenze) - Contractile remodelling in chronic atrial fibrilation: results from goat and human models

15.30 - 16.30 WP7 Integration and Modelling (Chairperson: P. Kohl)

• A. Garny (Oxford) - Integrative tools for cardiac elecdtrophysiological modelling: current status and application
• U. Ravens, E. Wettwer ( Dresden) - Isolated living heart slices from adult guinea pigs and rats as a model for drug testing

16.30 Coffee

17.00 - 16.30 WP8 Assessment of progress and Results & Dissemination activies (Chairperson: E. Cerbai)

• P. Kohl (Oxford) - From normaCOR to VPH: continuity of European research and integration efforts
• E. Cerbai (Firenze) - Present and future plan for dissemination and final report & presentation of the normaCOR project

18.00 - 18.30 General Discussion

20.30 Dinner (City Centre)

5 July 2009

9.00 - 10.30 Steering Committee Meeting (Co-ordinator and Team Leaders)

11.00 - 14.00 Guided Tour