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Lab web-page: http://mef.physiol.ox.ac.uk
Contact: peter.kohl@dpag.ox.ac.uk
Lay Summary:
The Oxford Mechano-Electric Feedback lab, led by Peter Kohl, has collaborations with different groups on both experimental and modelling projects. Current projects are on the sino-atrial node (with Dario DiFrancesco and David Eisner), atrial fibrillation structure and function (with Ursula Ravens and Ulrich Schotten), mechano-electric feedback and remodelling (with Elisabetta Cerbai and David Eisner), mechanical effects on drug efficacy (with Martin Biel) and the development and validation of modelling tools (with Dario DiFrancesco and Ursula Ravens. See http://www.cellml.org/ and http://cor.physiol.ox.ac.uk/ for some of the technologies and tools we use).
Relevant Publications:
- Kohl P & Noble D. Systems biology and the virtual physiological human. Molecular Systems Biology 2009/5:292-8.
- Iribe G & Kohl P. Axial stretch enhances sarcoplasmic reticulum Ca2+ leak and cellular Ca2+ reuptake in guinea pig myocytes: experiments and models. Prog Biophys Mol Biol 2008/97:298-311.
- de Boer T, Camelliti P, Ravens U & Kohl P. Myocardial tissue slices:organotypic pseudo-two-dimensional models for cardiac research and development. Future Cardiology 2009/5:425-430.
- Beard D, Britten R, Cooling MT, Garny A, Halstead MDB, Hunter PJ, Lawson J, Lloyd CM, Marsh J, Miller A, Nickerson D, Nielsen PMF, Nomura T, Subramanium S, Wimalaratne SM & Yu T. CellML metadata:standards, tools and repositories. Phil Trans R Soc A 2009/367:1845-1868.
- Iribe G, Ward CW, Camelliti P, Bollensdorff C, Mason F, Burton RAB, Garny A, Morphew MK, Hoenger A, Lederer WJ, Kohl P. Axial Stretch of Rat Single Ventricular Cardiomyocytes Causes an Acute and Transient Increase in Ca2 Spark Rate. Circulation Research 2009/104(6):787-95. (Link)
- Fenner JW et al.. The EuroPhysiome, STEP and a roadmap for the virtual physiological human.. Philosophical Transactions of the Royal Society A 2008/366:2979-2999. (Link)
- Clapworthy GJ, Kohl P, GregersonH et al. Digital Human Modelling: a Global Vision and a Eurpoean Perspective. Lecture Notes for Computer Science 2007/2674:459-558. (Link)
- Mansoori T, Plank G, Burton RAB, Schneider J, Kohl P, Gavaghan D & Grau V. An iterative method for registration of high-resolution cardiac histoanatomical and MRI images. IEEE ISBI 2007/April:572-575. (Link)
- Goodyer CE, Grau V, Mansoori T, Schneider JE, Brodlie KW & Kohl P. 3D visualization of cardiac anatomical MRI data with para-cellular resolution. Proceedings of IEEE EMBS 2007/Aug:147-151. (Link)
- Kohl P & Camelliti P. Cardiac myocyte - non-myocyte electronic couopling: Implications for ventricular arrhythmogenesis. Heart Rhythm 2007/4 (2):233-235. (Link)
- Plotkowiak M, Rodriguez B, Plank G, Schneider JE, Gavaghan D, Kohl P & Grau V. High performance computer simulations of cardiac electrical function based on high resolution MRI datasets.. Lecture Notes for Computer Science 2008/5101:571-580. (Link)
- Kohl P & Noble D. Life and mechanosensitivity.. Progress in Biophysics and Molecular Biology 2008/97:159-162.
- Goodyer C, Hodrien J, Wood J, Kohl P & Brodlie K. Using high resolution displays for high resolution cardiac data.. Philosophical Transactions of the Royal Society A 2009/367:2667-2677. (Link)
- Plank G, Burton RAB, Hales P, Bishop M, Mansoori T, Bernabeu M, Garny A, Prassl AJ, Bollensdorf C, Mason F, Rodriguez B, Grau V, Schneider J, Gavaghan D & Kohl P. Generation of hito-anatomically representative models of the individual heart: tools and application.. Philosophical Transactions of the Royal Society A 2009/367 (1896):2257-2292. (Link)
- Garny A, Noble D, Hunter PJ & Kohl P. Cellular open resource (COR): current status and future directions.. Philosophical Transactions of the Royal Society A 2009/367 (1895):1885-1905. (Link)
- Garny A, Nickerson D, Cooper J, Weber dos Santos R, McKeever S, Nielsen P & Hunter PJ. CellML and associated tools and techniques. Philosophical Transactions of the Royal Society A 2008/366 (1878):3017-42. (Link)
- Pitt-Francis J, Cooper J, Garny A, Momtahan L, Osborne J, Pathmanathan P, Rodriguez B, Whiteley J & Gavaghan D. Chaste: using agile programming techniques to develop computational biology software. Philosophical Transactions of the Royal Society A 2008/366 (1878):3111-36. (Link)
- Bishop MJ, Bub G, Garny A, Gavaghan DJ & Rodriguez B. An investigation into the role of the optical detection set-up in the recording of cardiac optical mapping signals: a Monte Carlo simulation study. Physica D: Nonlinear Phenomena 2009/238 (11-12):1008-1018.
- Stillitano F, Sartiani L, DePaoli P, Mugelli A & Cerbai E. Expression of the hyperpolarization-activated current, I[sub]F, in cultured adult rat ventricular cardiomyocytes and its modulation by hypertrophic factors. Pharmacological Research 2008/57(2):100-9.
- Iribe G, Helmes M & Kohl P. Force-length relations in isolated intact cariomyocytes subjected to dynamic changes in mechanical load. American Journal of Physiology 2007/292:1487-1497. (Link)
- Garny A & Noble D. CellML : de la cellule au medicament. Omniscience: "Biologie systémique" (eds. Ecrin & Roux M) 2007/:231-263.
- Camelliti P, Gallagher K, Kohl P & McCulloch A. Micropatterned cell cultures on elastic membranes as an in vitro model of myocardium. Nature Protocols 2006/1,3:1379-1391. (Link)
- Kohl P, Bollensdorff C & Garny A. Mechano-sensitive ion channels in the heart: experimental and theoretical models. Experimental Physiology 2006/91:307-321. (Link)
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