Subtasks:

• Detailed characterization of the blocking effect of ivabradine.
  • Status: in progress
  • Tangible Outcome:
    • Detailed characterization of the effect of ivabradine on HCN isoforms (mo.12).
• Synthesis and characterization of new HCN blockers.
  • Contribution:
    • Design and synthesis of novel compounds (mo.12) to be screened for their bradycardic effect; from these results, refined synthesis of HCN blockers and in-vitro characterization of their bradycardic effect and on blocking activity on HCN isoforms (mo.36).
  • Status: in progress
• Investigate mechanical effects on drug efficacy.
  • Status: in progress
  • Tangible Outcome:
    • Test compounds on structured cultures of cardiac cells mimicking SAN activity (mo.36).