Subtasks:

• Mechano-electrical feed-back (MEF) and remodelling.
  • Status: in progress
  • Tangible Outcome:
    • Data on the effect of exposure to ET-1 on the properties of cultured HL-1 cells (mo.12).
• Role of hypertrophic factors on atrial channel expression
  • Status: in progress
  • Tangible Outcome:
    • Detailed analysis of K channels abnormalities in human/goat AF tissue compared to healthy tissue (mo.12); and
    • In-vitro characterization of the electrophysiological activity of NCX blockers and AdoR agonists and insights into their antiarrhythmic properties (mo.36).
• Definition of targets of atrial remodelling.
  • Status: in progress
• New antiarrhythmic tools.
  • Status: in progress
  • Tangible Outcome:
    • novel methodological approaches (structured co-cultures, mo. 24) for studying the effect of MEF on electrophysiological remodelling (mo.36).