Subtasks:

• Mechanical properties of myofibrils from normal/diseased human atria.
  • Status: in progress
  • Tangible Outcome:
    • Validate use of human (mo.12) and goat (mo.24) myofibrils for mechanical experiments.
• Mechanical properties of atrial myofibrils in animal models of AF.
  • Status: in progress
  • Tangible Outcome:
    • Assess functional/molecular alterations in myofibrils in human AF and in the goat model of AF (mo.24).
• Assessment of titin/troponin content and effect of protein-exchange.
  • Status: in progress
  • Tangible Outcome:
    • Validate troponin exchange protocols in human atrial myofibrils (mo.36).