Subtasks:

• Mapping of atrial action potential.
  • Status: in progress
  • Tangible Outcome:
    • Validate multi-microelectrode array technique for atrial tissue aimed to assess atrial tissue heterogeneity and obtain an integrated assessment of drug action (mo.12).
• In silico predictions of drug effect on atrial action potential.
  • Status: in progress
  • Tangible Outcome:
    • Produce in silico predictions of drug actions, for known or new developed candidate drugs aimed to prevent initiation/domestication of AF or promote cardioversion (mo.36).
• Simulation of HCN - NCX interaction.
  • Status: in progress
• Model development and validation in the context of experimental data input
  • Status: in progress
  • Tangible Outcome:
    • Validate modelling tools (initially be made available to partners, mo.24), in form of platformindependent code (CellML, FieldML, AantML) (mo.36).