Normal Cardiac Excitation: Generation, Propagation and Coupling to Contraction

Project Background

Presentations



Background Publications


  • Nagy N, Szuts V, Horvath Z, Seprenyi G, Farkas AS, Acsai K, Prorok J, Bitay M, Kun A, Pataricza J, Papp JG, Nanasi PP, Varro A & Toth A. Does small-conductance calcium-activated potassium channel contribute to cardiac repolarization?. J Mol Cell Cardiol 2009/Jul:(epub ahead of print). 

  • Toth A, Kiss L, Varro A & Nanasi PP. Potential Therapeutic Effects of Na+/Ca2+ Exchanger Inhibition in Cardiac Diseases. Current Medicinal Chemistry 2009/16:3294-3321. 

  • Prorok J, Kovacs PP, Kristof AA, Nagy N, Tombacz D, Toth JS, Ordog B, Jost N, Virag L, Papp JG, Varro A, Toth A & Boldogkoi Z. Herpesvirus-Mediated Delivery of a Genetically Encoded Flourescent Ca2+ Sensor to Canine Cardiomyocytes. J Biomed Biotechnol 2009/361795:(epub). 

  • Virag L, Varro A, Acsai K, Hala O, Zaza A, Nanasi PP, Bitay M, Bogats G, Papp J Gy & Jost N. Self augmentation of the repolarization lengthening is related to the shape of the action potential: the role of the intrinsic properties of Ikr and its implication to reverse rate dependency. British Journal of Pharmacology 2009/156(7):1076-84. 

  • Greiser M, Neuberger H, Harks E, El-Armouche A, Boknik P, Verheyen F, Verheule S, Schmitz W, Ravens R, Nattel S, Allessie M, Dobrev D & Schotten U. Distinct Contractile and Molecular Alterations in Two Goat Models of Atrial Dysfunction: A V-Block-induced Atrial Dilation and Atrial Fibrillation. J Mol Cell Cardiol 2009/46:385-394. 

  • Nemtsas P, Wettwer E, Christ T, Weidinger G & Ravens U. Adult zebrafish heart as a model for human neart? An electrophysiological study. J Mol Cell Cardiol 2009/Sep 09:(epub ahead of print). 

  • Kohl P & Noble D. Systems biology and the virtual physiological human. Molecular Systems Biology 2009/5:292-8. 

  • Iribe G & Kohl P. Axial stretch enhances sarcoplasmic reticulum Ca2+ leak and cellular Ca2+ reuptake in guinea pig myocytes: experiments and models. Prog Biophys Mol Biol 2008/97:298-311. 

  • de Boer T, Camelliti P, Ravens U & Kohl P. Myocardial tissue slices:organotypic pseudo-two-dimensional models for cardiac research and development. Future Cardiology 2009/5:425-430. 

  • Beard D, Britten R, Cooling MT, Garny A, Halstead MDB, Hunter PJ, Lawson J, Lloyd CM, Marsh J, Miller A, Nickerson D, Nielsen PMF, Nomura T, Subramanium S, Wimalaratne SM & Yu T. CellML metadata:standards, tools and repositories. Phil Trans R Soc A 2009/367:1845-1868. 

  • Birinyi P, Toth A, Jona I, Acsai K, Almassy J, Nagy N, Prorok J, Gherasim I, Papp Z, Hertelendi Z, Szentandrassy N, Banyasz T, Fulop F, Papp J GY, Varro A, Nanasi PP & Magyar J. The Na+/Ca2+ exchange blocker SEA0400 fails to enhance cytostolic Ca2+ transient and contractility in canine ventricular cardiomyocytes. Cardiovascular Research 2008/78(3):476-84. 

  • Eisner DA, Kashimura T, Venetucci LA & Trafford WA. From the Ryanodine Receptor to Cardiac Arryhtmias. Circ J 2009/73:1561-1567. 

  • Walden AP, Dibb KM & Trafford AW. Differences in intracellular calcium homeostasis between atrial and ventricular myocytes. Journal of Molecular and Cellular Cardiology 2009/46:463-473. 

  • Dibb KM, Clarke JD, Horn MA, Richards MA, Graham MK, Eisner DA & Trafford AW. Characterization of an extensive transverse tubular network in sheep atrial myocytes and its depletion in heart failure. Circ Heart Fail 2009/2:482-489. 

  • Eisner D & Cerbai E. Beating to time: calcium clocks, voltage clocks and cardiac pacemaker activity. Am J Physiol Heart Circ Physiol 2009/296:H561-H562. 

  • Hoes E, Stieber J, Herrmann S, Feil S, Tybl E, Hofmann F, Feil R, Ludwig A. Tamoxifen-induced gene deletion in the cardiac conduction system. Journal of Molecular and Cellular Cardiology 2008/45:62-69. 

  • Biel M, Wahl-Schott C, Michalakis S & Zong X. Hyperpolarization-Activated Cation Channels: From Genes to Function. Physiol Rev 2009/89:847-885. 

  • Ravens U & Cerbai E. Role of potassium currents in cardiac arryhthmias. Europace 2008/10 (10):1133-7. 

  • Sartiani L, Suffredini S, Stillitano F, Del Lungo M, Jaconi M, Mugelli A & Cerbai E. Serotonin plays an obligatory role in cardiac differentiation. Laboratory Investigation 2009/xxx:xx-xx. 

  • Sartiani L, Stillitano F, Suffredini S, Brogioni S, Monici M, Mugelli A & Cerbai E. Chronic exposure to endothelin-1 affects the molecular and functional properties of the rapid delayed rectifier current. BBRC 2009/xxx:xx-xx. 

  • Stillitano F, Lonardo G, Zicha S, Varro A, Cerbai E, Mugelli A & Nattel S. Molecular Basis of Funny Current (If) in Normal and Failing Heart. J Mol Cell Cardiol 2008/45:289-299. 

  • Bussek A, Wettwer E, Christ T, Lohmann H, Camelliti P & Ravens U. Tissue slices from adult mammalian hearts as a model for pharmacological drug testing. Cell Physiol Biochem (in press) 2009/xxx:XXX. 

  • Voigt N, Rozmaritsa N, Trausch A, Zimniak T, Christ T, Wettwer E, Matschke K, Dobrev D & Ravens U. Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation. Naunyn-Schmiedeberg's Arch Pharmacol (in revision) 2009/(in press):xxx. 

  • Galvez BG, Sampaolesi M, Barbuti A, Crespi A, Covarello D, Brunelli S, Dellavalle A, Crippa S, Balconi G, Cuccovillo I, Molla F, Staszewsky L, Latini R, DiFrancesco D, Cossu G. Cardiac mesoangioblasts are committed, self-renewable progenitors, associated with small vessels of juvenile mouse ventricles. Cell Death Differ 2008/Sep; 15(9):1417-1428. 

  • Barbuti A, Crespi A, Capilupo D, Mazzocchi N, Baruscotti M, DiFrancesco D. Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells. J Mol Cell Cardiol 2009/Mar; 46(3):343-351. 

  • Lakatta EG, DiFrancesco D. What keeps us ticking: a funny current, a calcium clock, or both?. J Mol Cell Cardiol 2009/Aug 47(2):157-170. 

  • Brioschi C, Dobrzynski H, Terragni B, Tellez J, Psioni G, Longhi R, Moroni P, Billeter R, Baruscotti M, Boyett MR & DiFrancesco. Distribution of the pacemaker HCN4 channel protein in the rabbit sinoatrial node. J Mol Cell Cardiol 2009/Aug; 47(2):221-227. 

  • Baruscotti M, Barbuti A, Bucchi A. The cardiac pacemaker current. J Mol Cell Cardiol 2009/xxx:xx-xx. 

  • Iribe G, Ward CW, Camelliti P, Bollensdorff C, Mason F, Burton RAB, Garny A, Morphew MK, Hoenger A, Lederer WJ, Kohl P. Axial Stretch of Rat Single Ventricular Cardiomyocytes Causes an Acute and Transient Increase in Ca2 Spark Rate. Circulation Research 2009/104(6):787-95.  (Link)

  • Clapworthy GJ, Kohl P, GregersonH et al. Digital Human Modelling: a Global Vision and a Eurpoean Perspective. Lecture Notes for Computer Science 2007/2674:459-558.  (Link)

  • Mansoori T, Plank G, Burton RAB, Schneider J, Kohl P, Gavaghan D & Grau V. An iterative method for registration of high-resolution cardiac histoanatomical and MRI images. IEEE ISBI 2007/April:572-575.  (Link)

  • Goodyer CE, Grau V, Mansoori T, Schneider JE, Brodlie KW & Kohl P. 3D visualization of cardiac anatomical MRI data with para-cellular resolution. Proceedings of IEEE EMBS 2007/Aug:147-151.  (Link)

  • Kohl P & Camelliti P. Cardiac myocyte - non-myocyte electronic couopling: Implications for ventricular arrhythmogenesis. Heart Rhythm 2007/4 (2):233-235.  (Link)

  • Fenner JW et al.. The EuroPhysiome, STEP and a roadmap for the virtual physiological human.. Philosophical Transactions of the Royal Society A 2008/366:2979-2999.  (Link)

  • Plotkowiak M, Rodriguez B, Plank G, Schneider JE, Gavaghan D, Kohl P & Grau V. High performance computer simulations of cardiac electrical function based on high resolution MRI datasets.. Lecture Notes for Computer Science 2008/5101:571-580.  (Link)

  • Kohl P & Noble D. Life and mechanosensitivity.. Progress in Biophysics and Molecular Biology 2008/97:159-162. 

  • Goodyer C, Hodrien J, Wood J, Kohl P & Brodlie K. Using high resolution displays for high resolution cardiac data.. Philosophical Transactions of the Royal Society A 2009/367:2667-2677.  (Link)

  • Plank G, Burton RAB, Hales P, Bishop M, Mansoori T, Bernabeu M, Garny A, Prassl AJ, Bollensdorf C, Mason F, Rodriguez B, Grau V, Schneider J, Gavaghan D & Kohl P. Generation of hito-anatomically representative models of the individual heart: tools and application.. Philosophical Transactions of the Royal Society A 2009/367 (1896):2257-2292.  (Link)

  • Garny A, Noble D, Hunter PJ & Kohl P. Cellular open resource (COR): current status and future directions.. Philosophical Transactions of the Royal Society A 2009/367 (1895):1885-1905.  (Link)

  • Radicke S, Cotella D, Sblattero D, Ravens U, Santoro C & Wettwer E.. The transmembrane beta-subunits KCNE1, KCNE2, and DPP6 modify pharmacological effects of the antiarrhythmic agent tedisamil on the transient outward current Ito.. Naunyn-Schmied Arch Pharmacol 2009/379(6):617-627. 

  • Radicke S, Vaquero M, Caballero R, Gómez R, Núñez L, Tamargo J, Ravens U, Wettwer E & Delpón E.. Effects of MiRP1 and DPP6 beta-subunits on the blockade induced by flecainide of Kv4.3/KChIP2 channels.. Br J Pharmacol. 2008/154(4):774-786. 

  • Garny A, Nickerson D, Cooper J, Weber dos Santos R, McKeever S, Nielsen P & Hunter PJ. CellML and associated tools and techniques. Philosophical Transactions of the Royal Society A 2008/366 (1878):3017-42.  (Link)

  • Pitt-Francis J, Cooper J, Garny A, Momtahan L, Osborne J, Pathmanathan P, Rodriguez B, Whiteley J & Gavaghan D. Chaste: using agile programming techniques to develop computational biology software. Philosophical Transactions of the Royal Society A 2008/366 (1878):3111-36.  (Link)

  • Bishop MJ, Bub G, Garny A, Gavaghan DJ & Rodriguez B. An investigation into the role of the optical detection set-up in the recording of cardiac optical mapping signals: a Monte Carlo simulation study. Physica D: Nonlinear Phenomena 2009/238 (11-12):1008-1018. 

  • Stillitano F, Sartiani L, DePaoli P, Mugelli A & Cerbai E. Expression of the hyperpolarization-activated current, I[sub]F, in cultured adult rat ventricular cardiomyocytes and its modulation by hypertrophic factors. Pharmacological Research 2008/57(2):100-9. 

  • Garny A & Noble D. CellML : de la cellule au medicament. Omniscience: "Biologie systémique" (eds. Ecrin & Roux M) 2007/:231-263. 

  • Christ T, Wettwer E, Voigt N, Hála O, Radicke S, Matschke K, Várro A, Dobrev D &Ravens U . Pathology-specific effects of the IKur/Ito/IK,ACh blocker AVE0118 on ion channels in human chronic atrial fibrillation. Br J Pharmacol 2007/154(8):1619-1630. 

  • Greiser M, Halaszovich C, Frechen D, Boknik P, Ravens U, Dobrev D, Luckhoff A & Schotten U. Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillation. Naunyn Schmiedebergs Arch Pharmacol 2007/375:383-392. 

  • Blaauw Y, Schotten U, van Hunnik A, Neuberger H & Allessie M. Cardioversion of persistent atrial fibrillation by a combination of atrial specific and non-specific class III drugs in the goat. Cardiovasc Res 2007/75:89-98. 

  • Schotten U, de Haan S, Verheule S, Harks E, Frechen D, Bodewig E, Greiser M, Ram R, Maessen J, Kelm M, Allessie M & van Wagoner D. Blockade of atrial-specific K-currents increases atrial but not ventricular contractility by enhancing reverse mode Na/Ca-exchange. Cardiovasc Res 2007/73:37-47. 

  • Knaus A, Zong X, Beetz N, Jahns R, Lohse MJ, Biel M, Hein L. Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine. Circulation 2007/115(7):872-880.  (Link)

  • Bucchi A, Barbuti A, Baruscotti M, DiFrancesco D. Heart rate reduction via selective 'funny' channel blockers. Curr Opin Pharmacol 2007/7(2):208-213. 

  • Barbuti A, Baruscotti M, DiFrancesco D. The pacemaker current: from basics to the clinics. 2007 2007/18 (3):342-347. 

  • Bucchi A, Baruscotti M, Robinson RB, Difrancesco D. Modulation of rate by autonomic agonists in SAN cells involves changes in. J Mol Cell Cardiol 2007/43 (1):39-48. 

  • Barbuti A, Terragni B, Brioschi C & DiFrancesco D. Localization of f-channels to caveolae mediates specific beta2-adrenergic. J Mol Cell Cardiol 2007/42 :71-78. 

  • Barbuti A & DiFrancesco D. Control Of Cardiac Rate by 'Funny' Channels In Health And Disease. Ann NY Acad Sci 2007/11123:213-23. 

  • Wettwer E. Is there a functional correlate of Kv1.5 in the ventricle of canine heart and what would it mean for the use of IKur blockers?. Br J Pharmacol 2007/:1234-7890. 

  • Wettwer E, Christ T, Dobrev D & Ravens U.. Novel anti-arrhythmic agents for the treatment of atrial fibrillation. Curr Opin Pharmacol. 2007/7:214-218. 

  • Voigt N, Friedrich A, Bock M, Wettwer E, Christ T, Knaut M, Strasser RH, Ravens U & Dobrev D. Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated I(K,ACh) channels in patients with chronic atrial fibrillation. Cardiovascular Research 2007/74(3):426-437. 

  • Lengyel C, Virag L, Biro T, Jost N, Magyar J, Biliczki P, Kocsis E, Skoumal R, Nanasi PP, Toth M, Kecskemeti V, Papp JG & Varro A. Diabetes mellitus attenuates the repolarization reserve in mammalian heart. Cardiovascular Research 2007/73(3) / Feb 1:512-20.  (Link)

  • Gaborit N, Le Bouter S, Szuts V, Varro A, Escande D, Nattel S & Demolombe S. Regional and Tissue Specific Transcript Signatures of Ion Channel Genes in the Non-diseased Human Heart. Journal of Physiology 2007/May 3:(epub ahead of print).  (Link)

  • Schotten U, de Haan S, Verheule S, Harks EG, Frechen D, Bodewig E, Greiser M, Ram R, Maessen J, Kelm M, Allessie M, & van Wagoner DR. Blockade of atrial-specific K+-currents increases atrial but not ventricular contractility by enhancing reverse mode Na+/Ca2+-exchange. Cardiovascular Research 2007/73 (1) / Jan 1:37-47.  (Link)

  • Blaauw Y, Schotten U, van Hunnik A, Neuberger HR & Allessie MA. Cardioversion of persistent atrial fibrillation by a combination of atrial specific and non-specific class III drugs in the goat. Cardiovascular Research 2007/Mar 30:(epub ahead of print).  (Link)

  • Christ T, Wettwer E & Ravens U. Letter by Christ et al regarding article, "Angiotensin II potentiates the slow component of delayed rectifier K+ current via the AT1 receptor in guinea pig atrial myocytes".. Circulation 2007/114 (18):e565. 

  • Ventucci LL, Trafford AW & Eisner DA. Increasing ryanodine receptor open probability alone does not produce arrhythmogenic Ca waves: threshold SR Ca content is required. Circulation Research 2007/100:105-111.  (Link)

  • Sartiani L, Bettiol E, Stillitano F, Mugelli A, Cerbai E, Jaconi ME. Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach. Stem Cells 2007/May:1136 - 1144.  (Link)

  • Piroddi N, Belus A, Scellini B, Tesi C, Giunti G, Cerbai E, Mugelli A & Poggesi C. Tension generation and relaxation in single miofibrils from huma atrial and ventricular myocardium. Pflugers Archiv European Journal of Physiology 2007/454 (1) / April:63-73.  (Link)

  • Iribe G, Helmes M & Kohl P. Force-length relations in isolated intact cariomyocytes subjected to dynamic changes in mechanical load. American Journal of Physiology 2007/292:1487-1497.  (Link)

  • Mistrik P, Mader R, Michalakis S, Weidinger M, Pfeifer A, Biel M. The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides. J Biol Chem 2005/280(29):27056-27061.  (Link)

  • Wahl-Schott C, Baumann L, Zong X, Biel M. An arginine residue in the pore region is a key determinant of chloride dependence in cardiac pacemaker channels. J Biol Chem 2005/280(14):13694-13700.  (Link)

  • Zong X, Eckert C, Yuan H, Wahl-Schott C, Abicht H, Fang L, Li R, Mistrik P, Gerstner A, Much B, Baumann L, Michalakis S, Zeng R, Chen Z, Biel M. A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase. J Biol Chem 2005/280(40):34224-34232.  (Link)

  • Milanesi R, Baruscotti M, Gnecchi-Ruscone T, DiFrancesco D. Familial sinus bradycardia associated with a mutation in the cardiac pacemaker. N Engl J Med 2006/354(2):151-157. 

  • DiFrancesco D. Funny channels in the control of cardiac rhythm and mode of action of selective. Pharmacol Res 2006/53(5):399-406. 

  • El-Armouche A, Boknik P, Eschenhagen T, Carrier L, Knaut M, Ravens U & Dobrev D. Molecular determinants of altered Ca2+-handling in human chronic atrial fibrillation. Circulation 2006/114(7)/15 August:670-680.  (Link)

  • Christ T, Schindelhauer S, Wettwer E, Wallukat G & Ravens U. Interaction between autoantibodies against the β1-adrenoreceptor and isoprenaline in enhancing L-type Ca2+ current in rat ventricular myocytes. Journal of Molecular and Cellular Cardiology 2006/41:716-723.  (Link)

  • Dobrev D & Ravens U. Do genetics help to better understand the underlying mechanisms of atrial fibrillation?. European Heart Journal 2006/27(14):1640-1641.  (Link)

  • Cerbai E & Mugelli A. I(f) in non-pacemaker cells: role and pharmacological implications. Pharmacol Res. 2006/May 53 (5):416-423.  (Link)

  • Ventucci LL, Trafford AW, Diaz ME, O'Neill SC & Eisner DA. Reducing Ryanodine Receptor Open Probability As a Means to Abolish Spontaneous Ca2+ Release and Increase Ca2+ Transient Amplitude in Adult Ventricular Myocytes. Circulation Research 2006/98:1299-1305.  (Link)

  • Kupittayanant P, Trafford AW, Diaz M & Eisner DA. A mechanism distinct from the L-type Ca current or Na-Ca exchange contributes to Ca entry in rat ventricular myocytes. Cell Calcium 2006/39(5):417-23.  (Link)

  • Kohl P, Bollensdorff C & Garny A. Mechano-sensitive ion channels in the heart: experimental and theoretical models. Experimental Physiology 2006/91:307-321.  (Link)

  • Altomare C, Bescond J, Tognati A, Ferroni A & Baruscotti M. Direct inhibition of the pacemaker (If) current in rabbit sinoatrial node cells by genistein. British Journal of Pharmacology 2006/147:36–44.  (Link)

  • Ordog B, Brutyo E, Puskas LG, Papp JG, Varro A, Szabad J & Boldogkoi Z. Gene expression profiling of human cardiac potassium and sodium channels. International Journal of Cardiology 2006/111(3) / Aug 28:386-93.  (Link)

  • Radicke S, Cotella D, Graf EM, Banse U, Jost N, Varro A, Tseng GN, Ravens U & Wettwer E. Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts. Cardiovascular Research 2006/71(4) / Sep 1:695-703.  (Link)

  • Bucchi A, Tognati A, Milanesi R, Baruscotti M & DiFrancesco D. Properties of ivabradine-induced block of HCN1 and HCN4 channels. Journal of Physiology 2006/572:335-346.  (Link)

  • Wahl-Schott C, Baumann L, Cuny H, Eckert C, Griessmeier K & Biel M. Switching off caldium-dependent inactivation in L-type calcium channels by an autoinhibitory domain. Proceedings of the National Academy of Sciences 2006/103 (42) / 17 October:15657-15662.  (Link)

  • de Haan S, Greiser M, Harks E, Blaauw Y, van Hunnik A, Verheule S, Allessie M & Schotten U. VE0118, blocker of the transient outward current (I(to)) and ultrarapid delayed rectifier current (I(Kur)), fully restores atrial contractility after cardioversion of atrial fibrillation in the goat. Circulation 2006/114(12) / Sep 19:1234-42.  (Link)

  • Camelliti P, Gallagher K, Kohl P & McCulloch A. Micropatterned cell cultures on elastic membranes as an in vitro model of myocardium. Nature Protocols 2006/1,3:1379-1391.  (Link)

  • Mistrik P, Pfeifer A & Biel M. The enhancement of HCN channel instantaneous current facilitated by slow deactivation is regulated by intracellular chloride concentration. Pflugers Archiv European Journal of Physiology 2006/Sep 452 (6):718-727.  (Link)

  • Kirchhof P & Schotten U. Hypertension begets hypertrophy begets atrial fibrillation? Insights from yet another sheep model. Eur Heart J 2006/27:2919-2920. 

  • De Haan S, Greiser M, Harks E, Blaauw Y, van Hunnik A, Verheule S, Allessie M & Schotten U. AVE0118, Blocker of the Transient Outward Current (Ito) and Ultrarapid Delayed Rectifier Current (IKur), Fully Restores Atrial Contractility After Cardioversion of Atrial Fibrillation in the Goat. Circulation 2006/114:1234-1242. 

  • Goette A & Schotten U. Inhibition of angiotensin II type 1 receptors reduces atrial stunning and spontaneous echo contrast after electrical cardioversion of atrial fibrillation. Eur Heart J 2006/27:2034-2035. 

  • Eijsbouts S, Ausma J, Blaauw Y, Schotten U, Duytschaever M & Allessie M. Serial cardioversion by class IC Drugs during 4 months of persistent atrial fibrillation in the goat. J Cardiovasc Electrophysiol 2006/17:648-654. 

  • Schotten U, Dobrev D, Kirchhof P, Kääb S, Lewalter T, Goette A. Optimising the management of atrial fibrillation – insights from a national expert network. Deutsches Ärzteblatt 2006/103:A1743-1748. 

  • Allessie M & Schotten U. Paroxysmal atrial fibrillation: just a matter of nerves?. Heart Rhythm 2006/3:209-211. 

  • Neuberger H, Schotten U, Blaauw Y, Vollmann D, Eijsbouts S, van Hunnik A & Allessie M. Chronic atrial dilation, electrical remodeling, and atrial fibrillation in the goat. J Am Coll Cardiol 2006/47:644-653. 

  • Allessie M, Schotten U, Verheule S & Harks E. Gene therapy for repair of cardiac fibrosis: a long way to Tipperary. Circulation 2005/111:391-393. 

  • Vollman D, Blaauw Y, Neuberger H, Schotten U & Allessie M. Long-term changes in sequence of atrial activation and refractory periods: no evidence for "atrial memory". Heart Rhythm 2005/2:155-161. 

  • Neuberger H, Schotten U, Verheule S, Eijsbouts S, Blaauw Y, van Hunnik A & Allessie M. Development of a substrate of atrial fibrillation during chronic atrioventricular block in the goat. Circulation 2005/111:30-37. 

  • Blaauw Y, Gogelein H, Tieleman R, van Hunnik A, Schotten U & Allessie M. "Early" class III drugs for the treatment of atrial fibrillation: efficacy and atrial selectivity of AVE0118 in remodeled atria of the goat. Circulation 2004/110:1717-1724. 

  • Blaauw Y, Beier N, van der Voort P, van Hunnik A, Schotten U & Allessie M. Inhibitors of the Na+/H+ exchanger cannot prevent atrial electrical remodeling in the goat. J Cardiovasc Electrophysiol 2004/15:440-446. 

  • Schotten U, De Haan S, Neuberger H, Eijsbouts S, Blaauw Y, Tieleman R & Allessie M. Loss of Atrial Contractility is the Primary Cause of Atrial Dilatation during the first Days of Atrial Fibrillation. Am J Physiol Heart Circ Physiol 2004/287:H2324-H2331. 

  • Eijsbouts S, Houben R, Blaauw Y, Schotten U & Allessie M. Synergistic action of atrial dilation and sodium channel blockade on conduction in rabbit atria. J Cardiovasc Electrophysiol 2004/15:1453-1461. 

  • Er F, Larbig R, Ludwig A, Biel M, Hofmann F, Beuckelmann DJ, Hoppe UC. Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current I(f) and undermines spontaneous beating of neonatal cardiomyocytes. Circulation 2003/107(3):485-489.  (Link)

  • Much B, Wahl-Schott C, Zong X, Schneider A, Baumann L, Moosmang S, Ludwig A, Biel M. Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem 2003/278(44):43781-43786.  (Link)

  • Stieber J, Thomer A, Much B, Schneider A, Biel M, Hofmann F. Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4. J Biol Chem 2003/278(36):33672-33680.  (Link)

  • Schotten U, Neuberger H & Allessie M. The role of atrial dilatation during the domestication of atrial fibrillation. Proc Mol Biol Biophys 2003/82:151-162. 

  • Schotten U, Duytschaever M, Ausma J, Eijsbouts S, Neuberger H & Allessie M. Electrical and contractile remodeling during the first days of atrial fibrillation go hand-in-hand. Circulation 2003/107:1433-1439. 

  • Allessie M, Ausma J & Schotten U. Electrical, contractile and structural remodeling during atrial fibrillation. Cardiovasc Res 2002/54:230-246. 

  • Schotten U, Greiser M, Benke D, Buerkel K, Ehrenteidt B, Stellbrink C, Vazquez-Jimenez J, Schoendube F, Hanrath P & Allessie M. Atrial fibrillation-induced atrial contractile dysfunction: a tachycardiomyopathy of a different sort.. Cardiovasc Res 2002/53:192-201. 

  • Stieber J, Herrmann S, Feil S, Loster J, Feil R, Biel M, Hofmann F, Ludwig A. The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci U S A 2003/100(25):15235-15240.  (Link)

  • Moosmang S, Stieber J, Zong X, Biel M, Hofmann F, Ludwig A. Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. Eur J Biochem 2001/268(6):1646-1652.  (Link)

  • Schotten U, Ausma J, Stellbrink C, Sabatschus I, Vogel M, Frenchen D, Schoendube F, Hanrath P & Allessie M. Cellular mechanisms of depressed atrial contractility in patients with chronical atrial fibrillation.. Circulation 2001/103:691-698. 

  • Zong X, Stieber J, Ludwig A, Hofmann F, Biel M. A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2. J Biol Chem 2001/276(9):6313-6319.  (Link)

  • Vaca L, Stieber J, Zong X, Ludwig A, Hofmann F, Biel M. Mutations in the S4 domain of a pacemaker channel alter its voltage dependence. FEBS Lett 2000/479(1-2):35-40.  (Link)

  • Ludwig A, Zong X, Stieber J, Hullin R, Hofmann F, Biel M. Two pacemaker channels from human heart with profoundly different activation kinetics. Embo J 1999/18(9):2323-2329.  (Link)

  • Moosmang S, Biel M, Hofmann F, Ludwig A. Differential distribution of four hyperpolarization-activated cation channels in mouse brain. Biol Chem 1999/380(7-8):975-980.  (Link)

  • Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M. A family of hyperpolarization-activated mammalian cation channels. Nature 1998/393(6685):587-591.  (Link)